On the surface, Sadhguru's statement is a direct assertion of personal accountability. It means that the circumstances you find yourself in, the outcomes you experience, and the quality of your life are fundamentally determined by your own actions, choices, and attitudes. No external entity—be it fate, God, or other people—can absolve you of this ownership.

Within the Hindu worldview, this concept is deeply interwoven with the principles of karma and dharma. Your life is not a random event but a consequence of past actions (karma) and a field for fulfilling your present duties (dharma). The idea that 'life is your responsibility' aligns with the understanding that you are the creator of your own destiny through the continuous cycle of cause and effect. The Atman, the true Self, is not bound by external conditions but is the witness and experiencer of the unfolding drama of life, which it has, in essence, orchestrated. Therefore, recognizing this inherent responsibility is the first step towards liberation (moksha), as it empowers you to act consciously and align with your true nature, rather than being a passive victim of perceived external circumstances.

In your life: practice recognizing the agency you have in every situation, understanding that your reactions and efforts are the primary drivers of your experience.